Canada’s National Advisory Committee on Immunization (NACI) has changed guidelines for the AstraZeneca vaccine, now stating it can be given to people aged 65 and older. It had previously not been recommended for that age group due to an absence of clinical trial data on the vaccine’s effectiveness in that cohort. The updated guidance is based on “real world effectiveness” seen in countries using the AstraZeneca vaccine widely. NACI’s guidance states that the mRNA vaccines approved in Canada (Pfizer and Moderna) should be prioritized for use in people 65 years and older.